Let me present to you the most understandable, simplified, awesome analogy for explaining competitive and non competitive inhibitors =D
Hunger has affinity for food like enzymes have affinity for substrates.
Enzyme substrate affinity |
You happily eat it at some random rate.
Competitive inhibitors decrease affinity |
OBVIOUSLY, your affinity for the burger is more so you eat the burger instead.
The burger acts as a competitive inhibitor.
Lesson learnt: Competitive inhibitors reduces enzyme-substrate affinity.
Increasing substrate concentration - Competitive inhibitor |
The only way to reach the burger is to eat the rice..
So you eat the rice (since you are hungry anyway, duh!)
Lesson learnt: Competitive inhibitor concentration can be overcome by increasing the substrate concentration.
Preference to substrate than to the competitive inhibitor |
The increased concentration of the substrate!
Km, the substrate concentration to produce half of Vmax, had increased.
Lesson learnt: Km increases in presence of a competitive inhibitor.
Non competitive inhibitor |
The "gross thing" is a non competitive inhibitor.
Non competitive inhibitors decrease rate |
Vmax, the maximum rate of a chemical reaction, decreases.
Lesson learnt: Vmax decreases in presence of a non competitive inhibitor.
Increasing substrate - non competitive inhibitor |
Lesson learnt: Increasing substrate concentration will not affect the action of a non-competitive inhibitor.
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Woah,I must say whoever has made this is really very Creative!:) Loved it!;) Had fun too!:)
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Thank youuuuu so much!! <3
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